2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147336
    Desmethylazelastine
    Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
    Desmethylazelastine
  • HY-G0025
    Tetrabenazine Metabolite
    Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
    Tetrabenazine Metabolite
  • HY-P3147
    IYPTNGYTR
    IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism.
    IYPTNGYTR
  • HY-118167
    Monoethylglycinexylidide
    Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver[1].
    Monoethylglycinexylidide
  • HY-12771S
    O-Desmethyl Mebeverine acid-d5
    		98.45%
    O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<sub>5</sub>
  • HY-100057
    BMY 28674
    BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
    BMY 28674
  • HY-W701397
    Nicotinamide N-oxide-d4
    Nicotinamide N-oxide-d4 is the deuterium labeled Nicotinamide N-oxide (HY-101407). Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
    Nicotinamide N-oxide-d<sub>4</sub>
  • HY-143954S
    Epinephrine impurity 19-d3 hydrochloride
    Epinephrine impurity 19-d3 (hydrochloride) is the deuterium labeled Epinephrine impurity 19.
    Epinephrine impurity 19-d<sub>3</sub> hydrochloride
  • HY-113474R
    3,4-Dihydroxymandelic acid (Standard)
    3,4-Dihydroxymandelic acid (Standard) is the analytical standard of 3,4-Dihydroxymandelic acid. This product is intended for research and analytical applications. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    3,4-Dihydroxymandelic acid (Standard)
  • HY-150092
    8(S),9(R)-EET
    8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM.
    8(S),9(R)-EET
  • HY-B0199R
    Mycophenolate Mofetil (Standard)
    Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation.
    Mycophenolate Mofetil (Standard)
  • HY-126857S3
    5-Hydroxyomeprazole-d3-1
    5-Hydroxyomeprazole-d3-1 is the deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxyomeprazole-d<sub>3</sub>-1
  • HY-135410
    ABZ-amine
    ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.
    ABZ-amine
  • HY-131274
    Fexofenadine Impurity F
    Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.
    Fexofenadine Impurity F
  • HY-W357818
    Glycinexylidide
    Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease.
    Glycinexylidide
  • HY-143963S
    Irbesartan impurity 20-d4
    Irbesartan impurity 20-d4 is the deuterium labeled Irbesartan impurity 20. Irbesartan impurity 20-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Irbesartan impurity 20-d<sub>4</sub>
  • HY-149548
    2,3-Dinor-8-iso prostaglandin F1α
    2,3-Dinor-8-iso prostaglandin F1α is an isoprostanoid that can be used as a biomarker to assess psychological stress.
    2,3-Dinor-8-iso prostaglandin F1α
  • HY-143980S
    Losartan impurity 21-d4
    Losartan impurity 21-d4 is the deuterium labeled Losartan impurity 21. Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Losartan impurity 21-d<sub>4</sub>
  • HY-101416R
    Vanilpyruvic acid (Standard)
    Vanilpyruvic acid (Standard) is the analytical standard of Vanilpyruvic acid. This product is intended for research and analytical applications. Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
    Vanilpyruvic acid (Standard)
  • HY-12781S
    Desbutyl Lumefantrine-d9
    Desbutyl Lumefantrine-d9 is the deuterium labeled euterium labeled, which is a metabolite of Lumefantrine.
    Desbutyl Lumefantrine-d<sub>9</sub>
Cat. No. Product Name / Synonyms Application Reactivity